ACH Medical Journal. 2023; 2(3): 97-103 | DOI: 10.5505/achmedj.2023.00719

Abnormal Fetal Cardiac Function and Umbilical Cord Blood Brain Natriuretic Peptide Levels in Intrahepatic Cholestasis of Pregnancy

Ramazan Denizli¹, Ezgi Turgut¹, Nihat Farisoğulları¹, Bedri Sakcak¹, Atakan Tanacan¹, Kadir Cetinkaya², Nuray Yazihan³, Fuat Emre Canpolat⁴, Dilek Şahin^1
1Division of Perinatology, Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
²Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
³Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara University, Ankara, Turkey /Faculty of Medicine, Department of Pathophysiology, Ankara University, Ankara, Turkey
⁴Department Of Neonatology, Ministry Of Health, Ankara City Hospital, Ankara, Turkey

INTRODUCTION: We aim to evaluate fetal cardiac function and umbilical cord blood pro-BNP (pro-brain natriuretic peptide) levels in ICP (intrahepatic cholestasis of pregnancy).
METHODS: The study included 41 ICP cases and 41 controls. All participants were evaluated after 34 weeks of gestation. The pro-BNP levels in umbilical cord blood were assayed, and perinatal outcomes were compared between the groups.
RESULTS: In the ICP group SBA (serum bile acid) and pro-BNP levels were higher than the control group (p<0.001 and p=0.001). The left MPI (myocardial performance index) of ICP group was higher among the control group (p=0.043). A positive correlation was evaluated between the pro-BNP levels and MPI values (p<0.001).
DISCUSSION AND CONCLUSION: Both the high MPI values obtained via ultrasonography and the high pro-BNP levels detected in umbilical cord blood may be attributable to the adverse fetal cardiac effects of ICP.

Keywords: Fetal cardiac function, Fetal Doppler ultrasound, Intrahepatic cholestasis of pregnancy, Pro-brain natriuretic peptide, Serum bile acid.

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