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Abnormal Fetal Cardiac Function and Umbilical Cord Blood Brain Natriuretic Peptide Levels in Intrahepatic Cholestasis of Pregnancy
Ramazan Denizli1, Ezgi Turgut1, Nihat Farisoğulları1, Bedri Sakcak1, Atakan Tanacan1, Kadir Cetinkaya2, Nuray Yazihan3, Fuat Emre Canpolat4, Dilek Şahin11Division of Perinatology, Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey2Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
3Institute of Health Sciences, Interdisciplinary Food, Metabolism and Clinical Nutrition Department, Ankara University, Ankara, Turkey /Faculty of Medicine, Department of Pathophysiology, Ankara University, Ankara, Turkey
4Department Of Neonatology, Ministry Of Health, Ankara City Hospital, Ankara, Turkey
INTRODUCTION: We aim to evaluate fetal cardiac function and umbilical cord blood pro-BNP (pro-brain natriuretic peptide) levels in ICP (intrahepatic cholestasis of pregnancy).
METHODS: The study included 41 ICP cases and 41 controls. All participants were evaluated after 34 weeks of gestation. The pro-BNP levels in umbilical cord blood were assayed, and perinatal outcomes were compared between the groups.
RESULTS: In the ICP group SBA (serum bile acid) and pro-BNP levels were higher than the control group (p<0.001 and p=0.001). The left MPI (myocardial performance index) of ICP group was higher among the control group (p=0.043). A positive correlation was evaluated between the pro-BNP levels and MPI values (p<0.001).
DISCUSSION AND CONCLUSION: Both the high MPI values obtained via ultrasonography and the high pro-BNP levels detected in umbilical cord blood may be attributable to the adverse fetal cardiac effects of ICP.
Keywords: Fetal cardiac function, Fetal Doppler ultrasound, Intrahepatic cholestasis of pregnancy, Pro-brain natriuretic peptide, Serum bile acid.
Manuscript Language: English
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