Evaluation of Systemic Immune-Inflammation Index in Patients With Idiopathic Sudden Sensorineural Hearing LossIdiopathic Loss

INTRODUCTION: Systemic immune-inflammation index (SII) is an indicator of the inflammatory process. In this study we aimed to determine whether there is a relationship between the level of hearing loss and SII in patients diagnosed with idiopathic sudden sensorineural hearing loss (ISSHL), and to reveal whether SII has an indicator in the rate of improvement in hearing loss after treatment.
METHODS: Patients with ISSHL were included in the study. According to the audiometry performed before the initial treatment, the patients were divided into 3 groups (250, 500, 1000, 2000, 4000, 8000 Hz pure tone averages) below 40 dB defined as mild, between 40 and 80 dB defined as moderate and above 80 dB defined as severe.
RESULTS: In total 201 patients, 64 were in the mild hearing loss group, 115 in the moderate hearing loss group, and 22 in the severe hearing loss group. Multivariable logistic regression analysis revealed that higher SII [OR=1.002, 95% CI (1.001-1.003); p<0.001] associated with the severity of hearing loss. A statistically significant difference was found between the mean SII of the three groups (p<0.001). A negative correlation was found between improvement in hearing loss after treatment and SII levels. (R=-0.195, p<0.001). In addition, a negative correlation was found between the improvement in hearing loss and SII (R=-0.195, p<0.001).
DISCUSSION AND CONCLUSION: SII is an easily available and relatively cheap marker, was associated with the severity of hearing loss. In addition, it was also associated with the recovery of hearing loss.