XQuick Search
The role of 48-hour CRP/albumin ratio in the differential diagnosis of interstitial and necrotizing pancreatitis
Aziz Ahmet Surel1, Osman İnan2, Muhammet Kadri Colakoglu1, Erdal Birol Bostanci11Department Of General Surgery, Ankara City Hospital, Ankara, Turkey2Department of İnternal Medicine, Ankara City Hospital, Ankara, Turkey
INTRODUCTION: In this study, we aimed to examine the prognostic importance of the c – reactive protein (CRP)/albumin ratio in predicting acute necrotizing pancreatitis.
METHODS: The study included 100 patients diagnosed with acute interstitial pancreatitis and 50 patients diagnosed with necrotizing pancreatitis between 2015 and 2020, all over the age of 18.
RESULTS: The CRP/albumin ratio was higher in the acute necrotizing pancreatitis group compared to the interstitial pancreatitis group (94.0 vs 34.0; p <0.001, respectively). Multivariable analysis revealed CRP/albumin ratio [OR: 1.075 (1.029-1.123), p = 0.001], source of infection [OR: 4.698 (2.078-10.620), p < 0.001], and lactate dehydrogenase [OR: 1.006 (1.002-1.010), p = 0.004] to be significantly predictive of developing necrotizing pancreatitis. A prediction value of CRP/albumin ratio >70.6 was found to be a significant marker in predicting necrotizing pancreatitis (Sensitivity: 76.0%; Specificity: 85.4%; AUC: 0.881; p < 0.001). In addition, to demonstrate the nonlinear relationship between CRP/albumin and the probability of necrotizing pancreatitis, cubic spline regression analysis was applied, showing that the probability of necrotizing pancreatitis increased in relation to the increase of the CRP/albumin ratio.
DISCUSSION AND CONCLUSION: We conclude that the CRP/albumin ratio is a predictor of acute necrotizing pancreatitis. We believe that the CRP/albumin ratio is an inexpensive, sensitive, and easy-to-use predictor of acute necrotizing pancreatitis that can be used for both diagnosis and treatment follow-up.
Manuscript Language: English