ISSN :2822-5872
Northwestern Medical Journal
The effect of maternal asthma on serum PAPP-A levels and first trimester aneuploidy screening test running [ACH Medical Journal]
ACH Medical Journal. 2024; 3(2): 58-64 | DOI: 10.5505/achmedj.2024.72691

The effect of maternal asthma on serum PAPP-A levels and first trimester aneuploidy screening test running

Bergen Laleli Koc1, Gonca Türker Ergün2, Ozgur Kara1, Atakan Tanacan1, Deniz Oluklu1, Betül Akgün Aktaş1, Ecem Kaya1, Dilek Sahin1
1Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkey
2Department of Obstetrics and Gynecology, Turkish Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkey

INTRODUCTION: PAPP-A (Pregnancy-associated plasma protein-A) is considered a pro-inflammatory marker and its serum levels are elevated in non-pregnant patients with asthma. In the current research, we aimed to investigate whether maternal serum PAPP-A levels, a biomarker for first-trimester aneuploidy screening, differ in pregnant women with asthma compared to healthy pregnant women.
METHODS: In the first step, maternal serum PAPP-A MoM values, used as the first-trimester fetal aneuploidy screening marker, were compared between pregnant women with asthma and a healthy pregnant group. In the second step, the groups compared whether PAPP-A and fβ-HCG ( free β human chorionic gonadotropin) levels were below or above the cut-off values for Trisomy 21 and compared them according to maternal age (<35; ≥35).
RESULTS: The median PAPP-A level was found to be 2.15 IU/L (0.41-9.91) in the asthma group and 2.54 IU/L (0.56-11.40) in the control group, and there was no difference between the groups (P=0.363). The median PAPP-A MoM value was 0.99 (0.15-3.28) in the asthma group and 1.07 (0.33-3.37) in the control group. This result did not show a statistically significant difference (P = 0.694). No statistically significant difference was shown between the groups below and above 35 age (P=0.456).
DISCUSSION AND CONCLUSION: Maternal serum PAPP-A levels in pregnant women with asthma do not vary compared to the healthy pregnant group without asthma. Based on the results of our study, the first-trimester fetal aneuploidy screening test is a reliable screening method for pregnant women with asthma.

Keywords: Aneuploidy screening, Asthma, PAPP-A, Pregnancy

Bergen Laleli Koc, Gonca Türker Ergün, Ozgur Kara, Atakan Tanacan, Deniz Oluklu, Betül Akgün Aktaş, Ecem Kaya, Dilek Sahin. The effect of maternal asthma on serum PAPP-A levels and first trimester aneuploidy screening test running. ACH Medical Journal. 2024; 3(2): 58-64

Corresponding Author: Bergen Laleli Koc, Türkiye
Manuscript Language: English