ISSN :2822-5872
Northwestern Medical Journal
New prognostic markers in acute cholangitis patients with COVID-19 [ACH Medical Journal]
ACH Medical Journal. 2023; 2(2): 60-68 | DOI: 10.5505/achmedj.2023.88597

New prognostic markers in acute cholangitis patients with COVID-19

Fadime Güllü Haydar1, Yavuz Otal2, Gamze Avcıoğlu3
1Department of General Surgery,Ankara City Hospital, Ankara, Turkey
2Department of Emergency Medicine,Ankara City Hospital, Ankara, Turkey
3Department of Medical Biochemistry, Karadeniz Ereğli State Hospital,Zonguldak, Turkey

INTRODUCTION: COVID-19 is the cause of a pandemic with high mortality rates that affect the entire world. In the present study, the importance of blood parameters was investigated in predicting the severity of the disease in patients diagnosed with both covid19 and acute cholangitis simultaneously
METHODS: A total of 37 patient groups (n=37) who were diagnosed with both COVID-19 and acute cholangitis, a total of 38 patients in the control group (n=38) infected with Covid 19 and with no comorbidity, and 68 completely healthy control group (n) =68) were included in the study retrospectively and simultaneously. Those who had positive RT-PCR (Real-Time Polymerized Chain Reaction) test results were included in the study. The results of routine biochemistry, serology, hormone, and blood gas tests of the patients were compared with those of the control group. The Tokyo 2018 Criteria (TG18) were used in the diagnosis of acute cholangitis and disease severity grading.
RESULTS: The WBC(white blood cell), CRP(c-reactive protein), N/L Ratio(neutrophile/lynfosite ratio), AST(Aspartat Aminotransferaz), ALT(Alanin Aminotransferaz), LDH(Laktate dehidrogenaz), GGT(Gama glutamil transferaz), ALP(alkalen fosfataz) total bilirubin, and direct bilirubin levels were higher in the patient group at statistically significant levels than in the control group (p<0.001). The albumin levels were lower than in the control group (p<0.001). Total bilirubin/lymphocyte, GGT/lymphocyte, ALP/lymphocyte ratios, and D-dimer parameters had the highest AUC (Area Under the Curve) values in ROC analysis (0.984, 0.924, 0.923, and 0.897, respectively).
DISCUSSION AND CONCLUSION: Total bilirubin/lymphocyte, GGT/lymphocyte, and ALP/lymphocyte ratios may be useful in predicting the severity of the disease in acute cholangitis cases developing with COVID-19 simultaneously.

Keywords: COVID-19, acute cholangitis, total bilirubin, prognostic markers

Fadime Güllü Haydar, Yavuz Otal, Gamze Avcıoğlu. New prognostic markers in acute cholangitis patients with COVID-19. ACH Medical Journal. 2023; 2(2): 60-68

Corresponding Author: Fadime Güllü Haydar, Türkiye
Manuscript Language: English